The output of a quartz flexible accelerometer is influenced by temperature, and its temperature characteristics have complex functional characteristics. In this paper, a temperature compensation method for accelerometer zero bias is presented. A joint polynomial compensation model based on temperature and temperature gradient is established, and the corresponding test method is designed to calculate the compensation parameters. The experimental results show that this method is simple and effective, and it can compensate for the bias effect of quartz flexible accelerometer caused by temperature change, so as to achieve the purpose of improving the temperature and environmental adaptability of the system.