Due to the limit of high voltage power devices, the high voltage driving power for piezoelectric ceramics is still rare and expensive currently. The transformer can realize the transformation of voltage and current, and reasonable design can make it keep the good frequency response characteristic in a wide frequency range. A high voltage driving power for piezoelectric ceramics based on audio transformer is studied in this paper, and some experiments are conducted. A driving source with -3 dB bandwidth of 4 Hz~380 kHz at zero load and 600 V of peak to peak output voltage is fabricated, and it has the ability of driving a 2.5 nF capacitive load at 20 kHz at full power.