The piezoelectric drive method is widely used since it has the outstanding advantages of high mechanical durability,speed and great output strength,low power consumption as well as wide bandwidth.The drive requirements and ways of the piezoelectric drive are analyzed in the paper.The piezoelectric drive circuit is divided into DC boost converter module, DC voltage calibration module,switch amplifier drive module,AC voltage calibration module and control module in this paper.A twostage piezoelectric drive circuit system with simple structure,stable output and miniaturization is proposed.The design goal of converting the low voltage DC of 5 V into high voltage AC of 280 V has completed,and the amplitude, frequency and duty ratio of the square wave signal and sine wave signal can be changed freely.The load carrying capacity,output power and efficiency of the piezoelectric drive circuit are also analyzed in the paper.