Piezoelectric ceramic drive for digital potentiometer was designed, achieving piezoelectricity ceramic drive power supply on numerical control microscope objective. It was composed of single chip system, primary high voltage regulating circuit, numerical control potentiometers, power amplifier circuit, high voltage regulating power and discharge loop. It took primary high voltage regulation instead of voltage as the input, regulated by the high resolution numerical control potentiometers, and drove the piezoelectric ceramic drive by power amplifier and discharge loop. The output voltage of the driving power worked stably, and could be numerically adjusted and changed linearly according to the input voltage. It could critically control the voltage and was suitable for driving the dissolving load like voltage ceramic.