In order to improve the imaging quality of large numerical aperture projection lens,the high precision fine tuning for lens was required.The piezoelectric ceramic is a kind of high precision positioning actuator.According to the principle of the voltage controlled piezoelectric ceramic driving power,a high precision piezoelectric ceramic driving power for precision fine tuning of the lens has been designed by using the high voltage operational amplifier circuit consisting of operational amplifier PA88 and OPA2227.The design principles of the driving power supply and power supply were described in detail.The output voltage,linearity, static ripple and stability were simulated and analyzed using Multisim10 software.The results showed that the driving power had the advantages of high precision, maximum non linearity error of 0.000 5%,small static ripple(±100 nV) and strong stability,which reached the requirements for lens fine tuning.