In this paper, an intelligent transfusion monitoring system with vital signs monitoring sensor has been designed for real time measurement of patients′ pulse, body temperature, blood pressure (BP) and respiratory rate. The efficacy and safety of conducting vital signs intelligent monitoring in the transfusion of patients has been analyzed in detail. Taking the realization of full automatic intelligent measurement of electronic sphygmomanometer as an example, the design principle and method of SCM module of BP monitoring sensor and the interface of RF transceiver chip has also be described in this paper. It has been found that this system can conduct intelligent monitoring of every vital sign in the transfusion of patients with short distance wireless communication technology, can result in medical staff's not being on duty in the treatment of patients, and can solve many problems, and can solve many problems brought by nurse′s care at multiple spot, which is favorable for comprehensive treatment and management in combination with on line monitoring, safety warning of systems and emergency rescue.