According to the requirements of the ultrasonic motor and piezoelectric micro actuator for driving power supply, a kind of driving power supply is designed which can be used to drive both an ultrasonic motor and a micro actuator.The driving power supply is composed of an adjustable transformer, half bridge modules and the high performance digital signal processing(DSP) chip TMS320F28335 as the core control device. When driving the ultrasonic motor,the two phase ultrasonic frequency A.C. power output phase difference,the frequencies are large range continuous adjustable,When driving the piezoelectric micro actuator,the D.C. power output large range continuous adjustable. A series experiments on driving the traveling wave rotary ultrasonic motor and cymbal piezoelectric actuator show that the power supply can meet the driving requirements.