The Y3Fe5-2xZnxSnxO12(x=0~0.35) ferrites with Zn2+ and Sn4+ sustitution were prepared at 1 400 ℃ by the solid state method. The effects of Zn and Sn substitution content on the microstructure and magnetic properties of yttrium iron garnet ferrites were investigated. The results show that Zn2+ and Sn4+ entered into the crystal lattice of yttrium iron garnet ferrites. Moreover, with the increase of substitution content, the density and saturation magnetization of the yttrium iron garnet ferrites first increased, reached a maximum and then decreased. On the other hand, the magnetic loss of specimens first decreased, reached a minimum value at x=0.25 and then increased. As a result, it could effectively reduce the magnetic loss of yttrium iron garnet ferrite and control saturation magnetization of materials with a certain substitution content.