For the composite structure under the harmonic excitation, the vibration response of the structure is minimized by optimizing the stacking sequence, fiber angles and the distribution of piezoelectric material bonded on the surface of the composite structure. The piezoelectric effect of the piezoelectric material is simplified as the piezoelectric induced force. The discrete material optimization(DMO) method is used to model the piezoelectric composite structure. The local displacement response is taken as the optimization objective function with a given constraint of the mass, the optimization problem model is established, and the method of moving asymptotes(MMA) method is used to solve the optimization problem. The result of the numerical calculating example shows that the vibration response of the optimized design is significantly smaller than that of the initial design, which demonstrates the effectiveness of the optimization method.