To accurately monitor the intracranial pressure and temperature of patients and avoid the measurement errors such as noise and temperature drift of pressure sensors and temperature sensors, a sensor calibration and compensation algorithm is designed according to the performance characteristics of negative temperature coefficient thermistor and piezoresistive sensor in this paper. Firstly, the signal collected by the sensor is filtered to remove noise, and then the experiment is designed to compensate the temperature of the pressure sensor. The results show that the algorithm can effectively ensure that the intracranial temperature measurement error is within -0.1~+0.1 ℃ and the pressure measurement error is within -133.322~+133.322 Pa, which meets the requirements of clinical measurement range and accuracy.